Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-02 | Mississippi Valley State | 14 | Eastern Michigan | 61 | Final | W | 47 |
| 2 | 2016-09-10 | Eastern Michigan | 21 | Missouri | 61 | Final | L | -40 |
| 3 | 2016-09-17 | Eastern Michigan | 37 | Charlotte | 19 | Final | W | 18 |
| 4 | 2016-09-23 | Wyoming | 24 | Eastern Michigan | 27 | Final | W | 3 |
| 5 | 2016-10-01 | Eastern Michigan | 28 | Bowling Green | 25 | Final | W | 3 |
| 6 | 2016-10-08 | Toledo | 35 | Eastern Michigan | 20 | Final | L | -15 |
| 7 | 2016-10-15 | Eastern Michigan | 27 | Ohio | 20 | Final | W | 7 |
| 8 | 2016-10-22 | Eastern Michigan | 31 | Western Michigan | 45 | Final | L | -14 |
| 9 | 2016-10-29 | Miami (OH) | 28 | Eastern Michigan | 15 | Final | L | -13 |
| 10 | 2016-11-08 | Eastern Michigan | 48 | Ball State | 41 | Final | W | 7 |
| 11 | 2016-11-16 | Northern Illinois | 31 | Eastern Michigan | 24 | Final/OT | L | -7 |
| 12 | 2016-11-22 | Central Michigan | 21 | Eastern Michigan | 26 | Final | W | 5 |
| 13 | 2016-12-23 | Eastern Michigan | 20 | Old Dominion | 24 | Final | L | -4 |