Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-01 | Indiana | 34 | Florida International | 13 | Final | W | 21 |
| 2 | 2016-09-10 | Ball State (100) | 20 | Indiana (61) | 30 | Final | W | 10 |
| 3 | 2016-09-24 | Wake Forest (31) | 33 | Indiana (27) | 28 | Final | L | -5 |
| 4 | 2016-10-01 | Michigan State (58) | 21 | Indiana (37) | 24 | Final/OT | W | 3 |
| 5 | 2016-10-08 | Indiana (39) | 17 | Ohio State (5) | 38 | Final | L | -21 |
| 6 | 2016-10-15 | Nebraska (10) | 27 | Indiana (39) | 22 | Final | L | -5 |
| 7 | 2016-10-22 | Indiana (51) | 14 | Northwestern (63) | 24 | Final | L | -10 |
| 8 | 2016-10-29 | Maryland (40) | 36 | Indiana (70) | 42 | Final | W | 6 |
| 9 | 2016-11-05 | Indiana (58) | 33 | Rutgers (106) | 27 | Final | W | 6 |
| 10 | 2016-11-12 | Penn State (11) | 45 | Indiana (59) | 31 | Final | L | -14 |
| 11 | 2016-11-19 | Indiana (61) | 10 | Michigan (3) | 20 | Final | L | -10 |
| 12 | 2016-11-26 | Purdue (111) | 24 | Indiana (58) | 26 | Final | W | 2 |
| 13 | 2016-12-28 | Indiana (59) | 24 | Utah (38) | 26 | Final | L | -2 |