Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-03 | Miami (OH) (112) | 21 | Iowa (14) | 45 | Final | W | 24 |
| 2 | 2016-09-10 | Iowa State (98) | 3 | Iowa (14) | 42 | Final | W | 39 |
| 3 | 2016-09-17 | North Dakota State | 23 | Iowa | 21 | Final | L | -2 |
| 4 | 2016-09-24 | Iowa (110) | 14 | Rutgers (65) | 7 | Final | W | 7 |
| 5 | 2016-10-01 | Northwestern (102) | 38 | Iowa (70) | 31 | Final | L | -7 |
| 6 | 2016-10-08 | Iowa (91) | 14 | Minnesota (57) | 7 | Final | W | 7 |
| 7 | 2016-10-15 | Iowa (71) | 49 | Purdue (74) | 35 | Final | W | 14 |
| 8 | 2016-10-22 | Wisconsin (18) | 17 | Iowa (57) | 9 | Final | L | -8 |
| 9 | 2016-11-05 | Iowa (55) | 14 | Penn State (12) | 41 | Final | L | -27 |
| 10 | 2016-11-12 | Michigan (1) | 13 | Iowa (66) | 14 | Final | W | 1 |
| 11 | 2016-11-19 | Iowa (47) | 28 | Illinois (96) | 0 | Final | W | 28 |
| 12 | 2016-11-25 | Nebraska (14) | 10 | Iowa (43) | 40 | Final | W | 30 |
| 13 | 2017-01-02 | Florida (27) | 30 | Iowa (32) | 3 | Final | L | -27 |