Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-03 | Eastern Kentucky | 24 | Purdue | 45 | Final | W | 21 |
| 2 | 2016-09-10 | Cincinnati (64) | 38 | Purdue (99) | 20 | Final | L | -18 |
| 3 | 2016-09-24 | Nevada (97) | 14 | Purdue (92) | 24 | Final | W | 10 |
| 4 | 2016-10-01 | Purdue (69) | 7 | Maryland (29) | 50 | Final | L | -43 |
| 5 | 2016-10-08 | Purdue (81) | 34 | Illinois (86) | 31 | Final/OT | W | 3 |
| 6 | 2016-10-15 | Iowa (71) | 49 | Purdue (74) | 35 | Final | L | -14 |
| 7 | 2016-10-22 | Purdue (99) | 14 | Nebraska (8) | 27 | Final | L | -13 |
| 8 | 2016-10-29 | Penn State (18) | 62 | Purdue (98) | 24 | Final | L | -38 |
| 9 | 2016-11-05 | Purdue (104) | 31 | Minnesota (35) | 44 | Final | L | -13 |
| 10 | 2016-11-12 | Northwestern (58) | 45 | Purdue (107) | 17 | Final | L | -28 |
| 11 | 2016-11-19 | Wisconsin (8) | 49 | Purdue (111) | 20 | Final | L | -29 |
| 12 | 2016-11-26 | Purdue (111) | 24 | Indiana (58) | 26 | Final | L | -2 |