Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-02 | Furman | 13 | Michigan State | 28 | Final | W | 15 |
| 2 | 2016-09-17 | Michigan State (5) | 36 | Notre Dame (11) | 28 | Final | W | 8 |
| 3 | 2016-09-24 | Wisconsin (6) | 30 | Michigan State (35) | 6 | Final | L | -24 |
| 4 | 2016-10-01 | Michigan State (58) | 21 | Indiana (37) | 24 | Final/OT | L | -3 |
| 5 | 2016-10-08 | BYU (61) | 31 | Michigan State (77) | 14 | Final | L | -17 |
| 6 | 2016-10-15 | Northwestern (77) | 54 | Michigan State (89) | 40 | Final | L | -14 |
| 7 | 2016-10-22 | Michigan State (101) | 17 | Maryland (48) | 28 | Final | L | -11 |
| 8 | 2016-10-29 | Michigan (2) | 32 | Michigan State (104) | 23 | Final | L | -9 |
| 9 | 2016-11-05 | Michigan State (100) | 27 | Illinois (99) | 31 | Final | L | -4 |
| 10 | 2016-11-12 | Rutgers (105) | 0 | Michigan State (103) | 49 | Final | W | 49 |
| 11 | 2016-11-19 | Ohio State (2) | 17 | Michigan State (91) | 16 | Final | L | -1 |
| 12 | 2016-11-26 | Michigan State (89) | 12 | Penn State (8) | 45 | Final | L | -33 |