Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-03 | Murray State | 3 | Illinois | 52 | Final | W | 49 |
| 2 | 2016-09-10 | North Carolina (15) | 48 | Illinois (70) | 23 | Final | L | -25 |
| 3 | 2016-09-17 | Western Michigan | 34 | Illinois | 10 | Final | L | -24 |
| 4 | 2016-10-01 | Illinois (93) | 16 | Nebraska (14) | 31 | Final | L | -15 |
| 5 | 2016-10-08 | Purdue (81) | 34 | Illinois (86) | 31 | Final/OT | L | -3 |
| 6 | 2016-10-15 | Illinois (102) | 24 | Rutgers (97) | 7 | Final | W | 17 |
| 7 | 2016-10-22 | Illinois (89) | 8 | Michigan (2) | 41 | Final | L | -33 |
| 8 | 2016-10-29 | Minnesota (38) | 40 | Illinois (89) | 17 | Final | L | -23 |
| 9 | 2016-11-05 | Michigan State (100) | 27 | Illinois (99) | 31 | Final | W | 4 |
| 10 | 2016-11-12 | Illinois (89) | 3 | Wisconsin (9) | 48 | Final | L | -45 |
| 11 | 2016-11-19 | Iowa (47) | 28 | Illinois (96) | 0 | Final | L | -28 |
| 12 | 2016-11-26 | Illinois (97) | 21 | Northwestern (51) | 42 | Final | L | -21 |