Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | Liberty (53) | 29 | Southern Miss (144) | 27 | Final(4OT) | L | -2 |
| 2 | 2022-09-10 | Southern Miss (144) | 7 | Miami (41) | 30 | Final | L | -23 |
| 3 | 2022-09-17 | Northwestern State (257) | 10 | Southern Miss (101) | 62 | Final | W | 52 |
| 4 | 2022-09-24 | Southern Miss (73) | 27 | Tulane (47) | 24 | Final | W | 3 |
| 5 | 2022-10-08 | Southern Miss (78) | 10 | Troy (47) | 27 | Final | L | -17 |
| 6 | 2022-10-15 | Arkansas State (103) | 19 | Southern Miss (73) | 20 | Final | W | 1 |
| 7 | 2022-10-22 | Southern Miss (65) | 20 | Texas State (104) | 14 | Final | W | 6 |
| 8 | 2022-10-27 | Louisiana (99) | 24 | Southern Miss (53) | 39 | Final | W | 15 |
| 9 | 2022-11-05 | Georgia State (83) | 42 | Southern Miss (76) | 14 | Final | L | -28 |
| 10 | 2022-11-12 | Southern Miss (80) | 23 | Coastal Carolina (33) | 26 | Final | L | -3 |
| 11 | 2022-11-19 | South Alabama (31) | 27 | Southern Miss (84) | 20 | Final | L | -7 |
| 12 | 2022-11-26 | Southern Miss (82) | 20 | Louisiana-Monroe (119) | 10 | Final | W | 10 |
| 13 | 2022-12-17 | Rice (113) | 24 | Southern Miss (82) | 38 | Final | W | 14 |