Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | Houston Christian (254) | 46 | Northern Colorado (221) | 27 | Final | W | 19 |
| 2 | 2022-09-10 | Lindenwood | 21 | Houston Christian (254) | 20 | Final | L | -1 |
| 3 | 2022-09-24 | Houston Christian | 0 | Texas State (103) | 34 | Final | L | -34 |
| 4 | 2022-10-01 | Houston Christian | 37 | Lamar (259) | 34 | Final | W | 3 |
| 5 | 2022-10-08 | Nicholls State (244) | 19 | Houston Christian | 17 | Final | L | -2 |
| 6 | 2022-10-15 | Northwestern State (237) | 37 | Houston Christian | 10 | Final | L | -27 |
| 7 | 2022-10-22 | Houston Christian | 3 | Texas A&M-Commerce (181) | 31 | Final | L | -28 |
| 8 | 2022-10-29 | Tennessee-Martin (175) | 52 | Houston Christian | 28 | Final | L | -24 |
| 9 | 2022-11-05 | Houston Christian | 20 | Incarnate Word (116) | 73 | Final | L | -53 |
| 10 | 2022-11-12 | McNeese State (239) | 21 | Houston Christian | 10 | Final | L | -11 |
| 11 | 2022-11-19 | Houston Christian | 7 | Tarleton State (210) | 49 | Final | L | -42 |