Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-01 | Eastern Illinois (246) | 27 | Northern Illinois (68) | 34 | Final | L | -7 |
| 2 | 2022-09-10 | Chattanooga (159) | 38 | Eastern Illinois (246) | 20 | Final | L | -18 |
| 3 | 2022-09-17 | Eastern Illinois (231) | 7 | Illinois State (166) | 35 | Final | L | -28 |
| 4 | 2022-09-24 | Eastern Illinois (211) | 35 | Murray State (247) | 21 | Final | W | 14 |
| 5 | 2022-10-08 | Northwestern State (242) | 27 | Eastern Illinois (201) | 35 | Final | W | 8 |
| 6 | 2022-10-15 | Lindenwood (176) | 37 | Eastern Illinois (209) | 34 | Final(OT) | L | -3 |
| 7 | 2022-10-22 | Eastern Illinois (221) | 17 | Tennessee State (213) | 37 | Final | L | -20 |
| 8 | 2022-10-29 | Tennessee Tech (222) | 20 | Eastern Illinois (227) | 17 | Final | L | -3 |
| 9 | 2022-11-05 | Eastern Illinois (235) | 15 | McNeese State (238) | 29 | Final | L | -14 |
| 10 | 2022-11-12 | Southeast Missouri State (146) | 31 | Eastern Illinois (238) | 7 | Final | L | -24 |
| 11 | 2022-11-19 | Eastern Illinois (239) | 31 | Tennessee-Martin (181) | 34 | Final | L | -3 |