Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | Louisiana-Monroe (117) | 10 | Texas (47) | 52 | Final | L | -42 |
| 2 | 2022-09-10 | Nicholls State (162) | 7 | Louisiana-Monroe (117) | 35 | Final | W | 28 |
| 3 | 2022-09-17 | Louisiana-Monroe (108) | 7 | Alabama (4) | 63 | Final | L | -56 |
| 4 | 2022-09-24 | Louisiana (114) | 17 | Louisiana-Monroe (92) | 21 | Final | W | 4 |
| 5 | 2022-10-01 | Louisiana-Monroe (102) | 28 | Arkansas State (85) | 45 | Final | L | -17 |
| 6 | 2022-10-08 | Coastal Carolina (22) | 28 | Louisiana-Monroe (106) | 21 | Final | L | -7 |
| 7 | 2022-10-15 | Louisiana-Monroe (114) | 34 | South Alabama (29) | 41 | Final | L | -7 |
| 8 | 2022-10-22 | Louisiana-Monroe (125) | 24 | Army (102) | 48 | Final | L | -24 |
| 9 | 2022-11-05 | Texas State (115) | 30 | Louisiana-Monroe (118) | 31 | Final | W | 1 |
| 10 | 2022-11-12 | Louisiana-Monroe (107) | 31 | Georgia State (96) | 28 | Final | W | 3 |
| 11 | 2022-11-19 | Louisiana-Monroe (108) | 16 | Troy (27) | 34 | Final | L | -18 |
| 12 | 2022-11-26 | Southern Miss (82) | 20 | Louisiana-Monroe (119) | 10 | Final | L | -10 |