Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-02 | Austin Peay | 30 | Chattanooga | 20 | Final | W | 10 |
| 2 | 2021-09-11 | Austin Peay | 17 | Ole Miss | 54 | Final | L | -37 |
| 3 | 2021-09-18 | Morehead State | 35 | Austin Peay | 59 | Final | W | 24 |
| 4 | 2021-09-25 | Austin Peay | 27 | Eastern Kentucky | 35 | Final | L | -8 |
| 5 | 2021-10-02 | Tennessee State | 24 | Austin Peay | 22 | Final | L | -2 |
| 6 | 2021-10-09 | Southeast Missouri State | 30 | Austin Peay | 14 | Final | L | -16 |
| 7 | 2021-10-23 | Austin Peay | 47 | Murray State | 6 | Final | W | 41 |
| 8 | 2021-10-30 | Austin Peay | 16 | Tennessee-Martin | 17 | Final | L | -1 |
| 9 | 2021-11-06 | Eastern Illinois | 26 | Austin Peay | 42 | Final | W | 16 |
| 10 | 2021-11-13 | Austin Peay | 36 | Tennessee State | 7 | Final | W | 29 |
| 11 | 2021-11-20 | Tennessee Tech | 20 | Austin Peay | 48 | Final | W | 28 |