Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Davidson | 24 | Virginia Military | 45 | Final | L | -21 |
| 2 | 2021-09-11 | Shaw | 26 | Davidson | 28 | Final | W | 2 |
| 3 | 2021-09-25 | San Diego | 16 | Davidson | 28 | Final | W | 12 |
| 4 | 2021-10-02 | Davidson | 35 | Stetson | 28 | Final | W | 7 |
| 5 | 2021-10-16 | Presbyterian | 35 | Davidson | 70 | Final | W | 35 |
| 6 | 2021-10-23 | Davidson | 49 | Butler | 35 | Final | W | 14 |
| 7 | 2021-10-30 | Davidson | 29 | Morehead State | 22 | Final | W | 7 |
| 8 | 2021-11-06 | St. Thomas | 15 | Davidson | 42 | Final | W | 27 |
| 9 | 2021-11-13 | Davidson | 29 | Dayton | 38 | Final | L | -9 |
| 10 | 2021-11-20 | Drake | 14 | Davidson | 45 | Final | W | 31 |
| 11 | 2021-11-27 | Davidson (180) | 21 | Kennesaw State (112) | 48 | Final | L | -27 |