Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-08-27 | Austin Peay (169) | 27 | Western Kentucky (42) | 38 | Final | L | -11 |
| 2 | 2022-09-03 | Presbyterian (256) | 0 | Austin Peay (169) | 63 | Final | W | 63 |
| 3 | 2022-09-10 | Mississippi Valley State (209) | 0 | Austin Peay (169) | 41 | Final | W | 41 |
| 4 | 2022-09-17 | Austin Peay (144) | 28 | Alabama A&M (225) | 3 | Final | W | 25 |
| 5 | 2022-09-24 | Eastern Kentucky (149) | 20 | Austin Peay (138) | 31 | Final | W | 11 |
| 6 | 2022-10-01 | Austin Peay (162) | 20 | Central Arkansas (190) | 49 | Final | L | -29 |
| 7 | 2022-10-15 | Murray State (253) | 17 | Austin Peay (165) | 52 | Final | W | 35 |
| 8 | 2022-10-29 | Jacksonville State (143) | 40 | Austin Peay (171) | 16 | Final | L | -24 |
| 9 | 2022-11-05 | Austin Peay (171) | 38 | North Alabama (247) | 35 | Final | W | 3 |
| 10 | 2022-11-12 | Austin Peay (165) | 31 | Kennesaw State (187) | 14 | Final | W | 17 |
| 11 | 2022-11-19 | Austin Peay (167) | 0 | Alabama (6) | 34 | Final | L | -34 |