Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | Rice (119) | 14 | USC (93) | 66 | Final | L | -52 |
| 2 | 2022-09-10 | McNeese State (211) | 10 | Rice (119) | 52 | Final | W | 42 |
| 3 | 2022-09-17 | Louisiana (92) | 21 | Rice (58) | 33 | Final | W | 12 |
| 4 | 2022-09-24 | Rice (80) | 27 | Houston (56) | 34 | Final | L | -7 |
| 5 | 2022-10-01 | UAB (61) | 24 | Rice (62) | 28 | Final | W | 4 |
| 6 | 2022-10-15 | Rice (75) | 14 | Florida Atlantic (92) | 17 | Final | L | -3 |
| 7 | 2022-10-22 | Rice (72) | 42 | Louisiana Tech (116) | 41 | Final(OT) | W | 1 |
| 8 | 2022-10-29 | Charlotte (138) | 56 | Rice (100) | 23 | Final | L | -33 |
| 9 | 2022-11-03 | UTEP (120) | 30 | Rice (92) | 37 | Final | W | 7 |
| 10 | 2022-11-12 | Rice (98) | 10 | Western Kentucky (63) | 45 | Final | L | -35 |
| 11 | 2022-11-19 | UTSA (29) | 41 | Rice (107) | 7 | Final | L | -34 |
| 12 | 2022-11-26 | Rice (113) | 17 | North Texas (76) | 21 | Final | L | -4 |
| 13 | 2022-12-17 | Rice (113) | 24 | Southern Miss (82) | 38 | Final | L | -14 |