Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | Illinois State (184) | 0 | Wisconsin (14) | 38 | Final | L | -38 |
| 2 | 2022-09-10 | Valparaiso (237) | 21 | Illinois State (184) | 28 | Final | W | 7 |
| 3 | 2022-09-17 | Eastern Illinois (231) | 7 | Illinois State (166) | 35 | Final | W | 28 |
| 4 | 2022-10-01 | Southern Illinois (138) | 19 | Illinois State (174) | 14 | Final | L | -5 |
| 5 | 2022-10-08 | Illinois State (163) | 23 | Northern Iowa (189) | 21 | Final | W | 2 |
| 6 | 2022-10-15 | South Dakota (215) | 10 | Illinois State (161) | 12 | Final | W | 2 |
| 7 | 2022-10-22 | Illinois State (160) | 27 | Indiana State (228) | 21 | Final | W | 6 |
| 8 | 2022-10-29 | Illinois State (169) | 7 | North Dakota State (133) | 24 | Final | L | -17 |
| 9 | 2022-11-05 | Youngstown State (165) | 19 | Illinois State (174) | 17 | Final | L | -2 |
| 10 | 2022-11-12 | Illinois State (175) | 7 | South Dakota State (97) | 31 | Final | L | -24 |
| 11 | 2022-11-19 | Western Illinois (255) | 13 | Illinois State (179) | 20 | Final(OT) | W | 7 |