Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | Northern Iowa (138) | 17 | Air Force (28) | 48 | Final | L | -31 |
| 2 | 2022-09-10 | Northern Iowa (138) | 27 | North Dakota (155) | 29 | Final | L | -2 |
| 3 | 2022-09-17 | Sacramento State (148) | 37 | Northern Iowa (230) | 21 | Final | L | -16 |
| 4 | 2022-09-24 | Northern Iowa (199) | 52 | Western Illinois (256) | 17 | Final | W | 35 |
| 5 | 2022-10-01 | Indiana State (222) | 14 | Northern Iowa (183) | 20 | Final | W | 6 |
| 6 | 2022-10-08 | Illinois State (163) | 23 | Northern Iowa (189) | 21 | Final | L | -2 |
| 7 | 2022-10-15 | Utah Tech (233) | 14 | Northern Iowa (183) | 41 | Final | W | 27 |
| 8 | 2022-10-22 | Missouri State (190) | 20 | Northern Iowa (173) | 41 | Final | W | 21 |
| 9 | 2022-10-29 | Northern Iowa (164) | 37 | Southern Illinois (161) | 36 | Final | W | 1 |
| 10 | 2022-11-05 | South Dakota State (107) | 31 | Northern Iowa (167) | 28 | Final | L | -3 |
| 11 | 2022-11-19 | Northern Iowa (160) | 58 | South Dakota (199) | 14 | Final | W | 44 |