Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | South Dakota (140) | 0 | Kansas State (37) | 34 | Final | L | -34 |
| 2 | 2022-09-10 | South Dakota (140) | 7 | Montana (106) | 24 | Final | L | -17 |
| 3 | 2022-09-17 | Cal Poly (210) | 21 | South Dakota (184) | 38 | Final | W | 17 |
| 4 | 2022-09-24 | North Dakota State (142) | 34 | South Dakota (190) | 17 | Final | L | -17 |
| 5 | 2022-10-08 | South Dakota (203) | 3 | South Dakota State (138) | 28 | Final | L | -25 |
| 6 | 2022-10-15 | South Dakota (215) | 10 | Illinois State (161) | 12 | Final | L | -2 |
| 7 | 2022-10-22 | Southern Illinois (147) | 24 | South Dakota (193) | 27 | Final | W | 3 |
| 8 | 2022-10-29 | South Dakota (201) | 24 | Youngstown State (170) | 45 | Final | L | -21 |
| 9 | 2022-11-05 | Missouri State (191) | 13 | South Dakota (189) | 20 | Final | W | 7 |
| 10 | 2022-11-12 | South Dakota (193) | 19 | North Dakota (148) | 28 | Final | L | -9 |
| 11 | 2022-11-19 | Northern Iowa (160) | 58 | South Dakota (199) | 14 | Final | L | -44 |