Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-01 | North Alabama (214) | 14 | Indiana State (174) | 17 | Final(OT) | W | 3 |
| 2 | 2022-09-10 | Indiana State (174) | 0 | Purdue (18) | 56 | Final | L | -56 |
| 3 | 2022-09-17 | Montana (134) | 49 | Indiana State (205) | 14 | Final | L | -35 |
| 4 | 2022-10-01 | Indiana State (222) | 14 | Northern Iowa (183) | 20 | Final | L | -6 |
| 5 | 2022-10-08 | North Dakota State (137) | 31 | Indiana State (223) | 26 | Final | L | -5 |
| 6 | 2022-10-15 | Indiana State (226) | 42 | Youngstown State (178) | 48 | Final | L | -6 |
| 7 | 2022-10-22 | Illinois State (160) | 27 | Indiana State (228) | 21 | Final | L | -6 |
| 8 | 2022-10-29 | Indiana State (228) | 7 | South Dakota State (111) | 49 | Final | L | -42 |
| 9 | 2022-11-05 | North Dakota (152) | 42 | Indiana State (233) | 7 | Final | L | -35 |
| 10 | 2022-11-12 | Indiana State (229) | 21 | Western Illinois (256) | 0 | Final | W | 21 |
| 11 | 2022-11-19 | Missouri State (178) | 24 | Indiana State (231) | 7 | Final | L | -17 |