Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | South Dakota State (110) | 3 | Iowa (21) | 7 | Final | L | -4 |
| 2 | 2022-09-10 | UC-Davis (147) | 22 | South Dakota State (110) | 24 | Final | W | 2 |
| 3 | 2022-09-17 | Butler (214) | 17 | South Dakota State (141) | 45 | Final | W | 28 |
| 4 | 2022-09-24 | South Dakota State (139) | 28 | Missouri State (166) | 14 | Final | W | 14 |
| 5 | 2022-10-01 | Western Illinois (249) | 10 | South Dakota State (143) | 34 | Final | W | 24 |
| 6 | 2022-10-08 | South Dakota (203) | 3 | South Dakota State (138) | 28 | Final | W | 25 |
| 7 | 2022-10-15 | South Dakota State (126) | 23 | North Dakota State (145) | 21 | Final | W | 2 |
| 8 | 2022-10-22 | South Dakota State (118) | 49 | North Dakota (161) | 35 | Final | W | 14 |
| 9 | 2022-10-29 | Indiana State (228) | 7 | South Dakota State (111) | 49 | Final | W | 42 |
| 10 | 2022-11-05 | South Dakota State (107) | 31 | Northern Iowa (167) | 28 | Final | W | 3 |
| 11 | 2022-11-12 | Illinois State (175) | 7 | South Dakota State (97) | 31 | Final | W | 24 |
| 12 | 2022-12-03 | Delaware (135) | 6 | South Dakota State (91) | 42 | Final | W | 36 |
| 13 | 2022-12-10 | Holy Cross (71) | 21 | South Dakota State (91) | 42 | Final | W | 21 |
| 14 | 2022-12-17 | Montana State (102) | 18 | South Dakota State (91) | 39 | Final | W | 21 |
| 15 | 2023-01-08 | North Dakota State (114) | 21 | South Dakota State (91) | 45 | Final | W | 24 |