Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | Southern Illinois (137) | 29 | Incarnate Word (134) | 64 | Final | L | -35 |
| 2 | 2022-09-10 | Southeast Missouri State (190) | 34 | Southern Illinois (137) | 31 | Final | L | -3 |
| 3 | 2022-09-17 | Southern Illinois (156) | 31 | Northwestern (125) | 24 | Final | W | 7 |
| 4 | 2022-09-24 | North Dakota (172) | 17 | Southern Illinois (152) | 34 | Final | W | 17 |
| 5 | 2022-10-01 | Southern Illinois (138) | 19 | Illinois State (174) | 14 | Final | W | 5 |
| 6 | 2022-10-08 | Southern Illinois (129) | 38 | Missouri State (179) | 21 | Final | W | 17 |
| 7 | 2022-10-15 | Western Illinois (250) | 7 | Southern Illinois (131) | 30 | Final | W | 23 |
| 8 | 2022-10-22 | Southern Illinois (147) | 24 | South Dakota (193) | 27 | Final | L | -3 |
| 9 | 2022-10-29 | Northern Iowa (164) | 37 | Southern Illinois (161) | 36 | Final | L | -1 |
| 10 | 2022-11-12 | North Dakota State (127) | 21 | Southern Illinois (163) | 18 | Final | L | -3 |
| 11 | 2022-11-19 | Southern Illinois (169) | 21 | Youngstown State (168) | 28 | Final | L | -7 |