Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-01 | Western Illinois (204) | 25 | Tennessee-Martin (142) | 42 | Final | L | -17 |
| 2 | 2022-09-10 | Western Illinois (204) | 10 | Minnesota (26) | 62 | Final | L | -52 |
| 3 | 2022-09-17 | Southern Utah (172) | 17 | Western Illinois (254) | 10 | Final | L | -7 |
| 4 | 2022-09-24 | Northern Iowa (199) | 52 | Western Illinois (256) | 17 | Final | L | -35 |
| 5 | 2022-10-01 | Western Illinois (249) | 10 | South Dakota State (143) | 34 | Final | L | -24 |
| 6 | 2022-10-15 | Western Illinois (250) | 7 | Southern Illinois (131) | 30 | Final | L | -23 |
| 7 | 2022-10-22 | Youngstown State (178) | 28 | Western Illinois (249) | 27 | Final | L | -1 |
| 8 | 2022-10-29 | Western Illinois (253) | 14 | Missouri State (183) | 64 | Final | L | -50 |
| 9 | 2022-11-05 | North Dakota State (129) | 56 | Western Illinois (251) | 17 | Final | L | -39 |
| 10 | 2022-11-12 | Indiana State (229) | 21 | Western Illinois (256) | 0 | Final | L | -21 |
| 11 | 2022-11-19 | Western Illinois (255) | 13 | Illinois State (179) | 20 | Final(OT) | L | -7 |