Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-01 | South Carolina State (171) | 10 | Central Florida (50) | 56 | Final | L | -46 |
| 2 | 2022-09-10 | South Carolina State (171) | 33 | Bethune-Cookman (227) | 9 | Final | W | 24 |
| 3 | 2022-09-24 | South Carolina State (207) | 27 | North Carolina A&T (196) | 47 | Final | L | -20 |
| 4 | 2022-09-29 | South Carolina State (214) | 10 | South Carolina (69) | 50 | Final | L | -40 |
| 5 | 2022-10-08 | Florida A&M (188) | 20 | South Carolina State (225) | 14 | Final | L | -6 |
| 6 | 2022-10-15 | Virginia Lynchburg | 0 | South Carolina State (219) | 36 | Final | W | 36 |
| 7 | 2022-10-22 | North Carolina Central (172) | 24 | South Carolina State (200) | 26 | Final | W | 2 |
| 8 | 2022-10-29 | South Carolina State (211) | 14 | Morgan State (220) | 41 | Final | L | -27 |
| 9 | 2022-11-05 | Delaware State (212) | 27 | South Carolina State (225) | 24 | Final(OT) | L | -3 |
| 10 | 2022-11-12 | South Carolina State (231) | 14 | Howard (205) | 28 | Final | L | -14 |
| 11 | 2022-11-19 | Norfolk State (247) | 42 | South Carolina State (238) | 38 | Final | L | -4 |