Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-05 | Jackson State | 7 | Florida A&M | 6 | Final | L | -1 |
| 2 | 2021-09-11 | Fort Valley State | 7 | Florida A&M | 34 | Final | W | 27 |
| 3 | 2021-09-18 | Florida A&M | 17 | South Florida | 38 | Final | L | -21 |
| 4 | 2021-10-02 | Alabama State | 0 | Florida A&M | 28 | Final | W | 28 |
| 5 | 2021-10-09 | South Carolina State | 7 | Florida A&M | 30 | Final | W | 23 |
| 6 | 2021-10-16 | Florida A&M | 35 | Alabama A&M | 31 | Final | W | 4 |
| 7 | 2021-10-23 | Florida A&M | 31 | Mississippi Valley State | 28 | Final | W | 3 |
| 8 | 2021-10-30 | Grambling | 3 | Florida A&M | 26 | Final | W | 23 |
| 9 | 2021-11-06 | Florida A&M | 29 | Southern | 17 | Final | W | 12 |
| 10 | 2021-11-13 | Florida A&M | 37 | Arkansas-Pine Bluff | 7 | Final | W | 30 |
| 11 | 2021-11-20 | Bethune-Cookman | 21 | Florida A&M | 46 | Final | W | 25 |
| 12 | 2021-11-27 | Florida A&M (146) | 14 | Southeastern Louisiana (139) | 38 | Final | L | -24 |