Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Miles | 13 | Alabama State | 14 | Final(OT) | W | 1 |
| 2 | 2021-09-11 | Alabama State | 0 | Auburn | 62 | Final | L | -62 |
| 3 | 2021-09-25 | Bethune-Cookman | 24 | Alabama State | 38 | Final | W | 14 |
| 4 | 2021-10-02 | Alabama State | 0 | Florida A&M | 28 | Final | L | -28 |
| 5 | 2021-10-09 | Arkansas-Pine Bluff | 15 | Alabama State | 35 | Final | W | 20 |
| 6 | 2021-10-16 | Alabama State | 7 | Jackson State | 28 | Final | L | -21 |
| 7 | 2021-10-30 | Alabama State | 28 | Alabama A&M | 42 | Final | L | -14 |
| 8 | 2021-11-06 | Alabama State | 20 | Prairie View A&M | 24 | Final | L | -4 |
| 9 | 2021-11-13 | Alabama State | 31 | Mississippi Valley State | 44 | Final | L | -13 |
| 10 | 2021-11-20 | Texas Southern | 21 | Alabama State | 24 | Final | W | 3 |
| 11 | 2021-11-25 | Tuskegee | 9 | Alabama State (221) | 43 | Final | W | 34 |