Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-05 | Tennessee State | 10 | Grambling | 16 | Final | W | 6 |
| 2 | 2021-09-11 | Grambling | 0 | Southern Miss | 37 | Final | L | -37 |
| 3 | 2021-09-18 | Grambling | 0 | Houston | 45 | Final | L | -45 |
| 4 | 2021-09-25 | Prairie View A&M | 10 | Grambling | 24 | Final | W | 14 |
| 5 | 2021-10-02 | Alabama A&M | 28 | Grambling | 37 | Final | W | 9 |
| 6 | 2021-10-09 | Grambling | 20 | Alcorn State | 24 | Final | L | -4 |
| 7 | 2021-10-16 | Texas Southern | 20 | Grambling | 34 | Final | W | 14 |
| 8 | 2021-10-30 | Grambling | 3 | Florida A&M | 26 | Final | L | -23 |
| 9 | 2021-11-06 | Grambling | 26 | Arkansas-Pine Bluff | 33 | Final | L | -7 |
| 10 | 2021-11-13 | Bethune-Cookman | 31 | Grambling | 14 | Final | L | -17 |
| 11 | 2021-11-27 | Southern (232) | 26 | Grambling (182) | 29 | Final | W | 3 |