Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-05 | Jackson State | 7 | Florida A&M | 6 | Final | W | 1 |
| 2 | 2021-09-11 | Tennessee State | 16 | Jackson State | 38 | Final | W | 22 |
| 3 | 2021-09-18 | Jackson State | 7 | Louisiana-Monroe | 12 | Final | L | -5 |
| 4 | 2021-09-25 | Delta State | 17 | Jackson State | 24 | Final | W | 7 |
| 5 | 2021-10-08 | Jackson State | 61 | Alabama A&M | 15 | Final | W | 46 |
| 6 | 2021-10-09 | Jackson State | 61 | Alabama A&M | 15 | Final | W | 46 |
| 7 | 2021-10-16 | Alabama State | 7 | Jackson State | 28 | Final | W | 21 |
| 8 | 2021-10-23 | Bethune-Cookman | 12 | Jackson State | 42 | Final | W | 30 |
| 9 | 2021-10-30 | Jackson State | 28 | Mississippi Valley State | 19 | Final | W | 9 |
| 10 | 2021-11-06 | Texas Southern | 21 | Jackson State | 41 | Final | W | 20 |
| 11 | 2021-11-13 | Jackson State | 21 | Southern | 17 | Final | W | 4 |
| 12 | 2021-11-20 | Alcorn State | 10 | Jackson State | 24 | Final | W | 14 |
| 13 | 2021-12-04 | Prairie View A&M (204) | 10 | Jackson State (110) | 27 | Final | W | 17 |
| 14 | 2021-12-18 | South Carolina State (187) | 31 | Jackson State (110) | 10 | Final | L | -21 |