Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Bethune-Cookman | 28 | UTEP | 37 | Final | L | -9 |
| 2 | 2021-09-11 | Bethune-Cookman | 14 | Central Florida | 63 | Final | L | -49 |
| 3 | 2021-09-16 | Alabama A&M | 30 | Bethune-Cookman | 27 | Final | L | -3 |
| 4 | 2021-09-25 | Bethune-Cookman | 24 | Alabama State | 38 | Final | L | -14 |
| 5 | 2021-10-02 | Bethune-Cookman | 35 | South Carolina State | 42 | Final | L | -7 |
| 6 | 2021-10-09 | Mississippi Valley State | 20 | Bethune-Cookman | 14 | Final | L | -6 |
| 7 | 2021-10-16 | Prairie View A&M | 35 | Bethune-Cookman | 29 | Final | L | -6 |
| 8 | 2021-10-23 | Bethune-Cookman | 12 | Jackson State | 42 | Final | L | -30 |
| 9 | 2021-11-06 | Alcorn State | 31 | Bethune-Cookman | 35 | Final | W | 4 |
| 10 | 2021-11-13 | Bethune-Cookman | 31 | Grambling | 14 | Final | W | 17 |
| 11 | 2021-11-20 | Bethune-Cookman | 21 | Florida A&M | 46 | Final | L | -25 |