Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-02 | Mississippi Valley State | 0 | Murray State | 35 | Final | L | -35 |
| 2 | 2021-09-18 | Mississippi Valley State | 13 | Stephen F. Austin | 58 | Final | L | -45 |
| 3 | 2021-09-26 | Southern | 0 | Mississippi Valley State | 0 | Cancelled | - | - |
| 4 | 2021-10-02 | North Carolina Central | 16 | Mississippi Valley State | 17 | Final | W | 1 |
| 5 | 2021-10-09 | Mississippi Valley State | 20 | Bethune-Cookman | 14 | Final | W | 6 |
| 6 | 2021-10-16 | Alcorn State | 24 | Mississippi Valley State | 12 | Final | L | -12 |
| 7 | 2021-10-23 | Florida A&M | 31 | Mississippi Valley State | 28 | Final | L | -3 |
| 8 | 2021-10-30 | Jackson State | 28 | Mississippi Valley State | 19 | Final | L | -9 |
| 9 | 2021-11-06 | Mississippi Valley State | 14 | Alabama A&M | 42 | Final | L | -28 |
| 10 | 2021-11-13 | Alabama State | 31 | Mississippi Valley State | 44 | Final | W | 13 |
| 11 | 2021-11-27 | Mississippi Valley State (208) | 24 | Prairie View A&M (201) | 19 | Final | W | 5 |