Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Southern | 3 | Troy | 55 | Final | L | -52 |
| 2 | 2021-09-11 | Miles | 24 | Southern | 41 | Final | W | 17 |
| 3 | 2021-09-18 | McNeese State | 31 | Southern | 24 | Final | L | -7 |
| 4 | 2021-09-26 | Southern | 0 | Mississippi Valley State | 0 | Cancelled | - | - |
| 5 | 2021-10-09 | Texas Southern | 35 | Southern | 31 | Final | L | -4 |
| 6 | 2021-10-16 | Southern | 34 | Arkansas-Pine Bluff | 7 | Final | W | 27 |
| 7 | 2021-10-23 | Prairie View A&M | 48 | Southern | 21 | Final | L | -27 |
| 8 | 2021-10-30 | Alcorn State | 35 | Southern | 38 | Final | W | 3 |
| 9 | 2021-11-06 | Florida A&M | 29 | Southern | 17 | Final | L | -12 |
| 10 | 2021-11-13 | Jackson State | 21 | Southern | 17 | Final | L | -4 |
| 11 | 2021-11-27 | Southern (232) | 26 | Grambling (182) | 29 | Final | L | -3 |