Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | South Carolina State | 41 | Alabama A&M | 42 | Final | W | 1 |
| 2 | 2021-09-16 | Alabama A&M | 30 | Bethune-Cookman | 27 | Final | W | 3 |
| 3 | 2021-09-25 | Tuskegee | 35 | Alabama A&M | 45 | Final | W | 10 |
| 4 | 2021-10-02 | Alabama A&M | 28 | Grambling | 37 | Final | L | -9 |
| 5 | 2021-10-08 | Jackson State | 61 | Alabama A&M | 15 | Final | L | -46 |
| 6 | 2021-10-09 | Jackson State | 61 | Alabama A&M | 15 | Final | L | -46 |
| 7 | 2021-10-16 | Florida A&M | 35 | Alabama A&M | 31 | Final | L | -4 |
| 8 | 2021-10-30 | Alabama State | 28 | Alabama A&M | 42 | Final | W | 14 |
| 9 | 2021-11-06 | Mississippi Valley State | 14 | Alabama A&M | 42 | Final | W | 28 |
| 10 | 2021-11-13 | Alabama A&M | 52 | Texas Southern | 49 | Final | W | 3 |
| 11 | 2021-11-20 | Arkansas-Pine Bluff | 24 | Alabama A&M | 52 | Final | W | 28 |