Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Lane | 16 | Arkansas-Pine Bluff | 34 | Final | W | 18 |
| 2 | 2021-09-18 | Arkansas-Pine Bluff | 23 | Central Arkansas | 45 | Final | L | -22 |
| 3 | 2021-09-23 | Alcorn State | 39 | Arkansas-Pine Bluff | 38 | Final | L | -1 |
| 4 | 2021-09-30 | Arkansas-Pine Bluff | 17 | Prairie View A&M | 27 | Final | L | -10 |
| 5 | 2021-10-09 | Arkansas-Pine Bluff | 15 | Alabama State | 35 | Final | L | -20 |
| 6 | 2021-10-16 | Southern | 34 | Arkansas-Pine Bluff | 7 | Final | L | -27 |
| 7 | 2021-10-23 | Arkansas-Pine Bluff | 3 | Arkansas | 45 | Final | L | -42 |
| 8 | 2021-10-30 | Arkansas-Pine Bluff | 17 | Texas Southern | 59 | Final | L | -42 |
| 9 | 2021-11-06 | Grambling | 26 | Arkansas-Pine Bluff | 33 | Final | W | 7 |
| 10 | 2021-11-13 | Florida A&M | 37 | Arkansas-Pine Bluff | 7 | Final | L | -30 |
| 11 | 2021-11-20 | Arkansas-Pine Bluff | 24 | Alabama A&M | 52 | Final | L | -28 |