Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-18 | Holy Cross | 20 | Yale | 17 | Final | L | -3 |
| 2 | 2021-09-25 | Cornell | 17 | Yale | 23 | Final | W | 6 |
| 3 | 2021-10-02 | Yale | 34 | Lehigh | 0 | Final | W | 34 |
| 4 | 2021-10-09 | Yale | 17 | Dartmouth | 24 | Final(OT) | L | -7 |
| 5 | 2021-10-16 | Yale | 15 | Connecticut | 21 | Final | L | -6 |
| 6 | 2021-10-23 | Penn | 28 | Yale | 42 | Final | W | 14 |
| 7 | 2021-10-30 | Columbia | 30 | Yale | 37 | Final | W | 7 |
| 8 | 2021-11-06 | Yale | 63 | Brown | 38 | Final | W | 25 |
| 9 | 2021-11-13 | Yale | 20 | Princeton | 35 | Final | L | -15 |
| 10 | 2021-11-20 | Harvard | 34 | Yale | 31 | Final | L | -3 |