Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-18 | Harvard | 44 | Georgetown | 9 | Final | W | 35 |
| 2 | 2021-09-24 | Brown | 17 | Harvard | 49 | Final | W | 32 |
| 3 | 2021-10-02 | Harvard | 38 | Holy Cross | 13 | Final | W | 25 |
| 4 | 2021-10-09 | Cornell | 10 | Harvard | 24 | Final | W | 14 |
| 5 | 2021-10-16 | Lafayette | 3 | Harvard | 30 | Final | W | 27 |
| 6 | 2021-10-23 | Harvard | 16 | Princeton | 18 | Final(OT) | L | -2 |
| 7 | 2021-10-30 | Dartmouth | 20 | Harvard | 17 | Final | L | -3 |
| 8 | 2021-11-06 | Harvard | 49 | Columbia | 21 | Final | W | 28 |
| 9 | 2021-11-13 | Penn | 7 | Harvard | 23 | Final | W | 16 |
| 10 | 2021-11-20 | Harvard | 34 | Yale | 31 | Final | W | 3 |