Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-18 | Penn | 30 | Bucknell | 6 | Final | W | 24 |
| 2 | 2021-09-25 | Penn | 14 | Lafayette | 24 | Final | L | -10 |
| 3 | 2021-10-01 | Dartmouth | 31 | Penn | 7 | Final | L | -24 |
| 4 | 2021-10-09 | Lehigh | 0 | Penn | 20 | Final | W | 20 |
| 5 | 2021-10-16 | Penn | 14 | Columbia | 23 | Final | L | -9 |
| 6 | 2021-10-23 | Penn | 28 | Yale | 42 | Final | L | -14 |
| 7 | 2021-10-30 | Brown | 17 | Penn | 45 | Final | W | 28 |
| 8 | 2021-11-06 | Cornell | 15 | Penn | 12 | Final | L | -3 |
| 9 | 2021-11-13 | Penn | 7 | Harvard | 23 | Final | L | -16 |
| 10 | 2021-11-20 | Princeton | 34 | Penn | 14 | Final | L | -20 |