Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-18 | Rhode Island | 45 | Brown | 24 | Final | L | -21 |
| 2 | 2021-09-24 | Brown | 17 | Harvard | 49 | Final | L | -32 |
| 3 | 2021-10-02 | Brown | 29 | Bryant | 36 | Final | L | -7 |
| 4 | 2021-10-09 | Colgate | 10 | Brown | 31 | Final | W | 21 |
| 5 | 2021-10-16 | Princeton | 56 | Brown | 42 | Final | L | -14 |
| 6 | 2021-10-23 | Brown | 49 | Cornell | 45 | Final | W | 4 |
| 7 | 2021-10-30 | Brown | 17 | Penn | 45 | Final | L | -28 |
| 8 | 2021-11-06 | Yale | 63 | Brown | 38 | Final | L | -25 |
| 9 | 2021-11-13 | Brown | 17 | Columbia | 23 | Final | L | -6 |
| 10 | 2021-11-20 | Dartmouth | 52 | Brown | 31 | Final | L | -21 |