Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-18 | Virginia Military | 31 | Cornell | 21 | Final | L | -10 |
| 2 | 2021-09-25 | Cornell | 17 | Yale | 23 | Final | L | -6 |
| 3 | 2021-10-02 | Cornell | 10 | Bucknell | 21 | Final | L | -11 |
| 4 | 2021-10-09 | Cornell | 10 | Harvard | 24 | Final | L | -14 |
| 5 | 2021-10-15 | Colgate | 20 | Cornell | 34 | Final | W | 14 |
| 6 | 2021-10-23 | Brown | 49 | Cornell | 45 | Final | L | -4 |
| 7 | 2021-10-29 | Princeton | 34 | Cornell | 16 | Final | L | -18 |
| 8 | 2021-11-06 | Cornell | 15 | Penn | 12 | Final | W | 3 |
| 9 | 2021-11-13 | Cornell | 7 | Dartmouth | 41 | Final | L | -34 |
| 10 | 2021-11-20 | Columbia | 34 | Cornell | 26 | Final | L | -8 |