Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-03 | Southern Connecticut State | 28 | Central Connecticut State | 21 | Final | L | -7 |
| 2 | 2021-09-11 | Central Connecticut State | 21 | Wagner | 19 | Final | W | 2 |
| 3 | 2021-09-18 | Southeastern Louisiana | 56 | Central Connecticut State | 10 | Final | L | -46 |
| 4 | 2021-09-25 | Central Connecticut State | 0 | Miami | 69 | Final | L | -69 |
| 5 | 2021-10-09 | Columbia | 22 | Central Connecticut State | 20 | Final | L | -2 |
| 6 | 2021-10-16 | Central Connecticut State | 17 | Sacred Heart | 27 | Final | L | -10 |
| 7 | 2021-10-23 | Long Island | 30 | Central Connecticut State | 13 | Final | L | -17 |
| 8 | 2021-10-30 | Central Connecticut State | 49 | Merrimack | 21 | Final | W | 28 |
| 9 | 2021-11-06 | Bryant | 15 | Central Connecticut State | 30 | Final | W | 15 |
| 10 | 2021-11-13 | Central Connecticut State | 27 | Duquesne | 31 | Final | L | -4 |