Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-08-27 | Howard (243) | 13 | Alabama State (224) | 23 | Final | L | -10 |
| 2 | 2022-09-03 | Howard (243) | 28 | Hampton (212) | 31 | Final | L | -3 |
| 3 | 2022-09-10 | Howard (243) | 20 | South Florida (131) | 42 | Final | L | -22 |
| 4 | 2022-09-17 | Morehouse | 0 | Howard (233) | 31 | Final | W | 31 |
| 5 | 2022-10-01 | Howard (235) | 26 | Yale (161) | 34 | Final | L | -8 |
| 6 | 2022-10-15 | Harvard (172) | 41 | Howard (234) | 25 | Final | L | -16 |
| 7 | 2022-10-22 | Delaware State (218) | 17 | Howard (223) | 35 | Final | W | 18 |
| 8 | 2022-10-29 | Howard (212) | 49 | Norfolk State (247) | 21 | Final | W | 28 |
| 9 | 2022-11-05 | Howard (218) | 21 | North Carolina Central (166) | 50 | Final | L | -29 |
| 10 | 2022-11-12 | South Carolina State (231) | 14 | Howard (205) | 28 | Final | W | 14 |
| 11 | 2022-11-19 | Howard (200) | 35 | Morgan State (228) | 6 | Final | W | 29 |