Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | Tennessee Tech (310) | 59 | 89 | Indiana (46) | Final | L | -30 |
| 2 | 2020-11-30 | Chattanooga (291) | 62 | 54 | Tennessee Tech (310) | Final | L | -8 |
| 3 | 2020-12-02 | Tennessee Tech (310) | 48 | 79 | Xavier (92) | Final | L | -31 |
| 4 | 2020-12-03 | Tennessee Tech (310) | 65 | 74 | Northern Kentucky (195) | Final | L | -9 |
| 5 | 2020-12-06 | Tennessee Tech (310) | 75 | 76 | Western Carolina (223) | Final/OT | L | -1 |
| 6 | 2020-12-13 | Jacksonville State (227) | 73 | 67 | Tennessee Tech (310) | Final | L | -6 |
| 7 | 2020-12-16 | Tennessee Tech (310) | 50 | 74 | Jacksonville State (227) | Final | L | -24 |
| 8 | 2020-12-18 | Tennessee Tech (310) | 49 | 103 | Tennessee (18) | Final | L | -54 |
| 9 | 2020-12-22 | Tennessee Tech (310) | 68 | 88 | Western Kentucky (154) | Final | L | -20 |
| 10 | 2020-12-30 | Southeast Missouri State (226) | 63 | 72 | Tennessee Tech (310) | Final | W | 9 |
| 11 | 2021-01-02 | Tennessee Tech (310) | 81 | 87 | Eastern Illinois (314) | Final | L | -6 |
| 12 | 2021-01-07 | Tennessee Tech (310) | 54 | 57 | Morehead State (233) | Final | L | -3 |
| 13 | 2021-01-09 | Tennessee Tech (310) | 80 | 90 | Eastern Kentucky (288) | Final | L | -10 |
| 14 | 2021-01-14 | Belmont (68) | 88 | 67 | Tennessee Tech (310) | Final | L | -21 |
| 15 | 2021-01-16 | Tennessee State (165) | 71 | 74 | Tennessee Tech (310) | Final | W | 3 |
| 16 | 2021-01-21 | Tennessee Tech (310) | 69 | 72 | Austin Peay (138) | Final | L | -3 |
| 17 | 2021-01-23 | Tennessee Tech (310) | 63 | 72 | Murray State (116) | Final | L | -9 |
| 18 | 2021-01-28 | Eastern Kentucky (288) | 0 | 0 | Tennessee Tech (310) | Postponed | - | - |
| 19 | 2021-01-30 | Morehead State (233) | 74 | 55 | Tennessee Tech (310) | Final | L | -19 |
| 20 | 2021-02-04 | Tennessee Tech (310) | 64 | 68 | Southeast Missouri State (226) | Final | L | -4 |
| 21 | 2021-02-06 | Tennessee Tech (310) | 64 | 66 | Tennessee-Martin (205) | Final | L | -2 |
| 22 | 2021-02-11 | SIU-Edwardsville (248) | 81 | 63 | Tennessee Tech (310) | Final | L | -18 |
| 23 | 2021-02-13 | Eastern Illinois (314) | 67 | 80 | Tennessee Tech (310) | Final | W | 13 |
| 24 | 2021-02-15 | Eastern Kentucky (288) | 83 | 72 | Tennessee Tech (310) | Final | L | -11 |
| 25 | 2021-02-18 | Tennessee Tech (310) | 86 | 91 | Tennessee State (165) | Final | L | -5 |
| 26 | 2021-02-20 | Tennessee Tech (310) | 66 | 90 | Belmont (68) | Final | L | -24 |
| 27 | 2021-02-25 | Austin Peay (138) | 76 | 81 | Tennessee Tech (310) | Final | W | 5 |
| 28 | 2021-02-27 | Murray State (116) | 61 | 71 | Tennessee Tech (310) | Final | W | 10 |