Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | UTSA (232) | 0 | 0 | Oklahoma (39) | Cancelled | - | - |
| 2 | 2020-11-28 | Oklahoma (47) | 0 | 0 | Central Florida (43) | Cancelled | - | - |
| 3 | 2020-12-02 | Florida (163) | Oklahoma (200) | Cancelled | - | - | ||
| 4 | 2020-12-03 | UTSA (344) | 66 | 105 | Oklahoma (47) | Final | W | 39 |
| 5 | 2020-12-06 | Oklahoma (47) | 82 | 78 | TCU (32) | Final | W | 4 |
| 6 | 2020-12-09 | Oklahoma (47) | 77 | 99 | Xavier (92) | Final | L | -22 |
| 7 | 2020-12-12 | Florida A&M (297) | 54 | 85 | Oklahoma (47) | Final | W | 31 |
| 8 | 2020-12-16 | Oral Roberts (327) | 65 | 79 | Oklahoma (47) | Final | W | 14 |
| 9 | 2020-12-19 | Houston Baptist (323) | 65 | 84 | Oklahoma (51) | Final | W | 19 |
| 10 | 2020-12-22 | Texas Tech (20) | 69 | 67 | Oklahoma (47) | Final | L | -2 |
| 11 | 2021-01-02 | West Virginia (50) | 71 | 75 | Oklahoma (47) | Final | W | 4 |
| 12 | 2021-01-06 | Oklahoma (47) | 61 | 76 | Baylor (58) | Final | L | -15 |
| 13 | 2021-01-09 | Oklahoma (47) | 59 | 63 | Kansas (19) | Final | L | -4 |
| 14 | 2021-01-12 | TCU (32) | 46 | 82 | Oklahoma (47) | Final | W | 36 |
| 15 | 2021-01-16 | Oklahoma (47) | 0 | 0 | Oklahoma State (57) | Postponed | - | - |
| 16 | 2021-01-19 | Kansas State (96) | 50 | 76 | Oklahoma (47) | Final | W | 26 |
| 17 | 2021-01-23 | Kansas (19) | 68 | 75 | Oklahoma (47) | Final | W | 7 |
| 18 | 2021-01-26 | Oklahoma (47) | 80 | 79 | Texas (41) | Final | W | 1 |
| 19 | 2021-01-30 | Alabama (15) | 61 | 66 | Oklahoma (47) | Final | W | 5 |
| 20 | 2021-02-01 | Oklahoma (47) | 52 | 57 | Texas Tech (20) | Final | L | -5 |
| 21 | 2021-02-06 | Iowa State (7) | 72 | 79 | Oklahoma (47) | Final | W | 7 |
| 22 | 2021-02-10 | Baylor (58) | 0 | 0 | Oklahoma (47) | Cancelled | - | - |
| 23 | 2021-02-13 | Oklahoma (47) | 91 | 90 | West Virginia (50) | Final/2OT | W | 1 |
| 24 | 2021-02-18 | Texas (41) | 0 | 0 | Oklahoma (47) | Postponed | - | - |
| 25 | 2021-02-20 | Oklahoma (47) | 66 | 56 | Iowa State (7) | Final | W | 10 |
| 26 | 2021-02-23 | Oklahoma (47) | 57 | 62 | Kansas State (96) | Final | L | -5 |
| 27 | 2021-02-27 | Oklahoma State (57) | 94 | 90 | Oklahoma (47) | Final/OT | L | -4 |
| 28 | 2021-03-01 | Oklahoma (28) | 75 | 79 | Oklahoma State (20) | Final | L | -4 |
| 29 | 2021-03-04 | Texas (41) | 69 | 65 | Oklahoma (47) | Final | L | -4 |
| 30 | 2021-03-10 | Iowa State (265) | 73 | 79 | Oklahoma (34) | Final | W | 6 |
| 31 | 2021-03-11 | Oklahoma (47) | 62 | 69 | Kansas (19) | Final | L | -7 |
| 32 | 2021-03-20 | Missouri (34) | 68 | 72 | Oklahoma (37) | Final | W | 4 |
| 33 | 2021-03-22 | Oklahoma (37) | 71 | 87 | Gonzaga (1) | Final | L | -16 |