Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-27 | Valparaiso (156) | 71 | 77 | Vanderbilt (17) | Final | W | 6 |
| 2 | 2020-12-01 | Connecticut (4) | 0 | 0 | Vanderbilt (17) | Cancelled | - | - |
| 3 | 2020-12-01 | Connecticut (31) | Vanderbilt (75) | Cancelled | - | - | ||
| 4 | 2020-12-08 | Vanderbilt (17) | 0 | 0 | SMU (45) | Cancelled | - | - |
| 5 | 2020-12-08 | Vanderbilt (109) | SMU (21) | Cancelled | - | - | ||
| 6 | 2020-12-11 | North Carolina Central (341) | 0 | 0 | Vanderbilt (17) | Cancelled | - | - |
| 7 | 2020-12-11 | North Carolina Central (265) | Vanderbilt (109) | Cancelled | - | - | ||
| 8 | 2020-12-13 | Mississippi Valley State (365) | 41 | 84 | Vanderbilt (17) | Final | W | 43 |
| 9 | 2020-12-16 | Richmond (166) | 78 | 67 | Vanderbilt (17) | Final | L | -11 |
| 10 | 2020-12-19 | Radford (255) | 50 | 59 | Vanderbilt (17) | Final | W | 9 |
| 11 | 2020-12-22 | Vanderbilt (17) | 65 | 85 | Davidson (111) | Final | L | -20 |
| 12 | 2020-12-27 | Alcorn State (348) | 59 | 87 | Vanderbilt (17) | Final | W | 28 |
| 13 | 2020-12-30 | Florida (6) | 91 | 72 | Vanderbilt (17) | Final | L | -19 |
| 14 | 2021-01-05 | Vanderbilt (17) | 74 | 77 | Kentucky (26) | Final | L | -3 |
| 15 | 2021-01-09 | Mississippi State (100) | 84 | 81 | Vanderbilt (17) | Final | L | -3 |
| 16 | 2021-01-12 | Vanderbilt (180) | 0 | 0 | Missouri (18) | Cancelled | - | - |
| 17 | 2021-01-12 | Tennessee (18) | 0 | 0 | Vanderbilt (17) | Postponed | - | - |
| 18 | 2021-01-16 | Vanderbilt (17) | 61 | 81 | Tennessee (18) | Final | L | -20 |
| 19 | 2021-01-20 | Texas A&M (39) | 0 | 0 | Vanderbilt (17) | Cancelled | - | - |
| 20 | 2021-01-23 | Arkansas (16) | 92 | 71 | Vanderbilt (17) | Final | L | -21 |
| 21 | 2021-01-27 | Vanderbilt (17) | 71 | 78 | Florida (6) | Final | L | -7 |
| 22 | 2021-01-30 | South Carolina (110) | 81 | 93 | Vanderbilt (17) | Final | W | 12 |
| 23 | 2021-02-03 | Vanderbilt (17) | 0 | 0 | Texas A&M (39) | Cancelled | - | - |
| 24 | 2021-02-06 | Vanderbilt (17) | 70 | 73 | Georgia (35) | Final | L | -3 |
| 25 | 2021-02-09 | Auburn (37) | 73 | 67 | Vanderbilt (17) | Final | L | -6 |
| 26 | 2021-02-13 | Vanderbilt (17) | 72 | 51 | Mississippi State (100) | Final | W | 21 |
| 27 | 2021-02-17 | Kentucky (26) | 82 | 78 | Vanderbilt (17) | Final | L | -4 |
| 28 | 2021-02-20 | Vanderbilt (17) | 78 | 82 | Alabama (15) | Final | L | -4 |
| 29 | 2021-02-24 | Tennessee (18) | 70 | 58 | Vanderbilt (17) | Final | L | -12 |
| 30 | 2021-02-27 | Ole Miss (79) | 70 | 75 | Vanderbilt (17) | Final | W | 5 |
| 31 | 2021-03-02 | Vanderbilt (17) | 68 | 83 | LSU (77) | Final | L | -15 |
| 32 | 2021-03-04 | Vanderbilt (17) | 78 | 64 | Cincinnati (54) | Final | W | 14 |
| 33 | 2021-03-06 | Vanderbilt (17) | 46 | 56 | Ole Miss (79) | Final | L | -10 |
| 34 | 2021-03-10 | Texas A&M (131) | 68 | 79 | Vanderbilt (135) | Final | W | 11 |
| 35 | 2021-03-11 | Vanderbilt (17) | 63 | 69 | Florida (6) | Final | L | -6 |