Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | Oklahoma State (57) | 75 | 68 | Texas-Arlington (162) | Final | W | 7 |
| 2 | 2020-11-28 | Texas Southern (317) | 65 | 85 | Oklahoma State (57) | Final | W | 20 |
| 3 | 2020-12-01 | Oklahoma State (57) | 70 | 62 | Marquette (106) | Final | W | 8 |
| 4 | 2020-12-05 | Oakland (172) | 71 | 84 | Oklahoma State (57) | Final | W | 13 |
| 5 | 2020-12-08 | Oral Roberts (327) | 78 | 83 | Oklahoma State (57) | Final | W | 5 |
| 6 | 2020-12-12 | Oklahoma State (57) | 67 | 64 | Wichita State (76) | Final | W | 3 |
| 7 | 2020-12-16 | TCU (32) | 77 | 76 | Oklahoma State (57) | Final | L | -1 |
| 8 | 2020-12-20 | Oklahoma State (57) | 74 | 77 | Texas (41) | Final | L | -3 |
| 9 | 2021-01-02 | Oklahoma State (57) | 82 | 77 | Texas Tech (20) | Final/OT | W | 5 |
| 10 | 2021-01-04 | West Virginia (50) | 87 | 84 | Oklahoma State (57) | Final | L | -3 |
| 11 | 2021-01-09 | Oklahoma State (57) | 70 | 54 | Kansas State (96) | Final | W | 16 |
| 12 | 2021-01-12 | Kansas (19) | 70 | 75 | Oklahoma State (57) | Final | W | 5 |
| 13 | 2021-01-16 | Oklahoma (47) | 0 | 0 | Oklahoma State (57) | Postponed | - | - |
| 14 | 2021-01-19 | Oklahoma State (57) | 0 | 0 | West Virginia (50) | Postponed | - | - |
| 15 | 2021-01-23 | Baylor (58) | 81 | 66 | Oklahoma State (57) | Final | L | -15 |
| 16 | 2021-01-25 | Oklahoma State (57) | 81 | 60 | Iowa State (7) | Final | W | 21 |
| 17 | 2021-01-30 | Arkansas (16) | 77 | 81 | Oklahoma State (57) | Final | W | 4 |
| 18 | 2021-02-03 | Oklahoma State (57) | 78 | 81 | TCU (32) | Final | L | -3 |
| 19 | 2021-02-06 | Texas (41) | 67 | 75 | Oklahoma State (57) | Final/2OT | W | 8 |
| 20 | 2021-02-08 | Oklahoma State (57) | 66 | 78 | Kansas (19) | Final | L | -12 |
| 21 | 2021-02-13 | Kansas State (96) | 60 | 67 | Oklahoma State (57) | Final | W | 7 |
| 22 | 2021-02-16 | Iowa State (7) | 58 | 76 | Oklahoma State (57) | Final | W | 18 |
| 23 | 2021-02-20 | Oklahoma State (57) | 0 | 0 | Baylor (58) | Postponed | - | - |
| 24 | 2021-02-22 | Texas Tech (20) | 69 | 74 | Oklahoma State (57) | Final/OT | W | 5 |
| 25 | 2021-02-27 | Oklahoma State (57) | 94 | 90 | Oklahoma (47) | Final/OT | W | 4 |
| 26 | 2021-03-01 | Oklahoma (28) | 75 | 79 | Oklahoma State (20) | Final | W | 4 |
| 27 | 2021-03-04 | Oklahoma State (57) | 70 | 81 | Baylor (58) | Final | L | -11 |
| 28 | 2021-03-06 | Oklahoma State (57) | 85 | 80 | West Virginia (50) | Final | W | 5 |
| 29 | 2021-03-11 | Oklahoma State (57) | 72 | 69 | West Virginia (50) | Final | W | 3 |
| 30 | 2021-03-12 | Oklahoma State (57) | 83 | 74 | Baylor (58) | Final | W | 9 |
| 31 | 2021-03-13 | Oklahoma State (17) | 86 | 91 | Texas (16) | Final | L | -5 |
| 32 | 2021-03-19 | Liberty (86) | 60 | 69 | Oklahoma State (14) | Final | W | 9 |
| 33 | 2021-03-21 | Oregon State (69) | 80 | 70 | Oklahoma State (14) | Final | L | -10 |