Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-29 | Arkansas-Pine Bluff (303) | 63 | 80 | Iowa State (7) | Final | W | 17 |
| 2 | 2020-12-02 | South Dakota State (268) | 71 | 68 | Iowa State (7) | Final | L | -3 |
| 3 | 2020-12-06 | DePaul (95) | 0 | 0 | Iowa State (7) | Cancelled | - | - |
| 4 | 2020-12-11 | Iowa State (7) | 77 | 105 | Iowa (28) | Final | L | -28 |
| 5 | 2020-12-15 | Kansas State (96) | 74 | 65 | Iowa State (7) | Final | L | -9 |
| 6 | 2020-12-18 | Iowa State (7) | 65 | 70 | West Virginia (50) | Final | L | -5 |
| 7 | 2020-12-20 | Jackson State (329) | 45 | 60 | Iowa State (7) | Final | W | 15 |
| 8 | 2020-12-22 | Chicago State (351) | 0 | 0 | Iowa State (7) | Cancelled | - | - |
| 9 | 2020-12-22 | Chicago State (357) | Deprecated: htmlspecialchars(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/allmysportsteamssuck.com/ncaa-college-basketball-schedule/index.php on line 160 |
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Iowa State (258) | Cancelled | - | - |
| 10 | 2021-01-02 | Baylor (58) | 76 | 65 | Iowa State (7) | Final | L | -11 |
| 11 | 2021-01-05 | Iowa State (7) | 72 | 78 | Texas (41) | Final | L | -6 |
| 12 | 2021-01-09 | Texas Tech (20) | 91 | 64 | Iowa State (7) | Final | L | -27 |
| 13 | 2021-01-13 | Iowa State (7) | 0 | 0 | Kansas State (96) | Postponed | - | - |
| 14 | 2021-01-16 | Iowa State (7) | 0 | 0 | Kansas (19) | Postponed | - | - |
| 15 | 2021-01-20 | Texas (41) | 0 | 0 | Iowa State (7) | Postponed | - | - |
| 16 | 2021-01-23 | Iowa State (7) | 0 | 0 | Texas Tech (20) | Postponed | - | - |
| 17 | 2021-01-25 | Oklahoma State (57) | 81 | 60 | Iowa State (7) | Final | L | -21 |
| 18 | 2021-01-30 | Iowa State (7) | 56 | 95 | Mississippi State (100) | Final | L | -39 |
| 19 | 2021-02-02 | West Virginia (50) | 76 | 72 | Iowa State (7) | Final | L | -4 |
| 20 | 2021-02-06 | Iowa State (7) | 72 | 79 | Oklahoma (47) | Final | L | -7 |
| 21 | 2021-02-09 | Iowa State (7) | 76 | 79 | TCU (32) | Final | L | -3 |
| 22 | 2021-02-11 | Iowa State (7) | 64 | 97 | Kansas (19) | Final | L | -33 |
| 23 | 2021-02-13 | Kansas (19) | 64 | 50 | Iowa State (7) | Final | L | -14 |
| 24 | 2021-02-16 | Iowa State (7) | 58 | 76 | Oklahoma State (57) | Final | L | -18 |
| 25 | 2021-02-18 | Texas (12) | 0 | 0 | Iowa State (251) | Cancelled | - | - |
| 26 | 2021-02-20 | Oklahoma (47) | 66 | 56 | Iowa State (7) | Final | L | -10 |
| 27 | 2021-02-23 | Iowa State (7) | 72 | 77 | Baylor (58) | Final | L | -5 |
| 28 | 2021-02-27 | TCU (32) | 76 | 72 | Iowa State (7) | Final | L | -4 |
| 29 | 2021-03-02 | Texas (41) | 81 | 67 | Iowa State (7) | Final | L | -14 |
| 30 | 2021-03-04 | Iowa State (7) | 54 | 81 | Texas Tech (20) | Final | L | -27 |
| 31 | 2021-03-06 | Iowa State (7) | 56 | 61 | Kansas State (96) | Final | L | -5 |
| 32 | 2021-03-10 | Iowa State (265) | 73 | 79 | Oklahoma (34) | Final | L | -6 |