Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-27 | Texas-Arlington (162) | 71 | 76 | Louisiana Tech (185) | Final | W | 5 |
| 2 | 2020-11-29 | Northwestern State (315) | 77 | 91 | Louisiana Tech (185) | Final | W | 14 |
| 3 | 2020-12-03 | Louisiana-Monroe (358) | 62 | 78 | Louisiana Tech (185) | Final | W | 16 |
| 4 | 2020-12-06 | Louisiana Tech (185) | 55 | 86 | LSU (77) | Final | L | -31 |
| 5 | 2020-12-09 | Southeastern Louisiana (318) | 69 | 78 | Louisiana Tech (185) | Final | W | 9 |
| 6 | 2020-12-12 | Louisiana Tech (185) | 56 | 61 | Louisiana (290) | Final | L | -5 |
| 7 | 2020-12-15 | Jackson State (329) | 58 | 85 | Louisiana Tech (185) | Final | W | 27 |
| 8 | 2020-12-19 | Lamar (279) | 57 | 86 | Louisiana Tech (185) | Final | W | 29 |
| 9 | 2020-12-22 | Louisiana Tech (185) | 68 | 57 | Louisiana-Monroe (358) | Final | W | 11 |
| 10 | 2021-01-01 | Marshall (155) | 68 | 75 | Louisiana Tech (185) | Final | W | 7 |
| 11 | 2021-01-02 | Marshall (155) | 80 | 73 | Louisiana Tech (185) | Final | L | -7 |
| 12 | 2021-01-08 | Louisiana Tech (185) | 64 | 66 | Western Kentucky (154) | Final | L | -2 |
| 13 | 2021-01-09 | Louisiana Tech (185) | 63 | 58 | Western Kentucky (154) | Final | W | 5 |
| 14 | 2021-01-15 | UTSA (344) | 66 | 77 | Louisiana Tech (185) | Final | W | 11 |
| 15 | 2021-01-16 | UTSA (344) | 66 | 82 | Louisiana Tech (185) | Final | W | 16 |
| 16 | 2021-01-22 | Louisiana Tech (185) | 74 | 82 | UTEP (274) | Final | L | -8 |
| 17 | 2021-01-23 | Louisiana Tech (185) | 73 | 55 | UTEP (274) | Final | W | 18 |
| 18 | 2021-01-28 | Louisiana Tech (185) | 76 | 63 | Southern Miss (201) | Final | W | 13 |
| 19 | 2021-01-30 | Southern Miss (201) | 62 | 65 | Louisiana Tech (185) | Final | W | 3 |
| 20 | 2021-02-05 | Louisiana Tech (185) | 68 | 63 | North Texas (125) | Final | W | 5 |
| 21 | 2021-02-06 | Louisiana Tech (185) | 55 | 57 | North Texas (125) | Final | L | -2 |
| 22 | 2021-02-12 | UAB (115) | 58 | 70 | Louisiana Tech (185) | Final | W | 12 |
| 23 | 2021-02-13 | UAB (115) | 64 | 69 | Louisiana Tech (185) | Final | W | 5 |
| 24 | 2021-02-19 | Louisiana Tech (185) | 0 | 0 | Middle Tennessee (164) | Cancelled | - | - |
| 25 | 2021-02-20 | Louisiana Tech (185) | 0 | 0 | Middle Tennessee (164) | Cancelled | - | - |
| 26 | 2021-02-21 | Louisiana Tech (185) | 0 | 0 | Middle Tennessee (164) | Cancelled | - | - |
| 27 | 2021-02-26 | Rice (228) | 57 | 101 | Louisiana Tech (185) | Final | W | 44 |
| 28 | 2021-02-27 | Rice (228) | 58 | 79 | Louisiana Tech (185) | Final | W | 21 |
| 29 | 2021-03-03 | Lady of the Lake | 66 | 99 | Louisiana Tech (185) | Final | W | 33 |
| 30 | 2021-03-11 | Florida Atlantic (128) | 69 | 75 | Louisiana Tech (185) | Final | W | 6 |
| 31 | 2021-03-12 | North Texas (125) | 54 | 48 | Louisiana Tech (185) | Final | L | -6 |
| 32 | 2021-03-19 | Louisiana Tech (70) | 70 | 61 | Ole Miss (60) | Final | W | 9 |
| 33 | 2021-03-25 | Louisiana Tech (70) | 72 | 65 | Western Kentucky (65) | Final | W | 7 |
| 34 | 2021-03-27 | Louisiana Tech (70) | 62 | 84 | Mississippi State (82) | Final | L | -22 |
| 35 | 2021-03-28 | Louisiana Tech (70) | 76 | 74 | Colorado State (52) | Final | W | 2 |