Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | Texas Southern (317) | 52 | 56 | Washington State (179) | Final | L | -4 |
| 2 | 2020-11-28 | Texas Southern (317) | 65 | 85 | Oklahoma State (57) | Final | L | -20 |
| 3 | 2020-11-30 | Texas Southern (317) | 76 | 74 | Wyoming (103) | Final | W | 2 |
| 4 | 2020-12-03 | Texas Southern (317) | 70 | 82 | Saint Mary's (33) | Final | L | -12 |
| 5 | 2020-12-11 | LeTourneau | 60 | 103 | Texas Southern (317) | Final | W | 43 |
| 6 | 2020-12-15 | Texas Southern (317) | 63 | 80 | Auburn (37) | Final | L | -17 |
| 7 | 2020-12-21 | Texas Southern (317) | 71 | 87 | BYU (23) | Final | L | -16 |
| 8 | 2020-12-23 | Texas Southern (317) | 0 | 0 | USC (71) | Cancelled | - | - |
| 9 | 2020-12-23 | Texas Southern (205) | USC (30) | Cancelled | - | - | ||
| 10 | 2020-12-30 | Texas Southern (214) | TCU (57) | Cancelled | - | - | ||
| 11 | 2021-01-02 | Texas Southern (317) | 0 | 0 | Alcorn State (348) | Cancelled | - | - |
| 12 | 2021-01-03 | Texas Southern (317) | 0 | 0 | Southern (259) | Cancelled | - | - |
| 13 | 2021-01-09 | Texas Southern (317) | 0 | 0 | Prairie View A&M (285) | Postponed | - | - |
| 14 | 2021-01-11 | Texas Southern (317) | 67 | 73 | Prairie View A&M (285) | Final | L | -6 |
| 15 | 2021-01-16 | Grambling (312) | 78 | 72 | Texas Southern (317) | Final | L | -6 |
| 16 | 2021-01-18 | Jackson State (329) | 0 | 0 | Texas Southern (317) | Cancelled | - | - |
| 17 | 2021-01-23 | Texas Southern (317) | 66 | 57 | Arkansas-Pine Bluff (303) | Final | W | 9 |
| 18 | 2021-01-25 | Texas Southern (317) | 0 | 0 | Mississippi Valley State (365) | Cancelled | - | - |
| 19 | 2021-01-30 | Alabama State (331) | 73 | 80 | Texas Southern (317) | Final | W | 7 |
| 20 | 2021-02-01 | Alabama A&M (286) | 49 | 66 | Texas Southern (317) | Final | W | 17 |
| 21 | 2021-02-06 | UTRGV (161) | 75 | 77 | Texas Southern (317) | Final | W | 2 |
| 22 | 2021-02-13 | Texas Southern (317) | 75 | 73 | Grambling (312) | Final | W | 2 |
| 23 | 2021-02-15 | Texas Southern (192) | 0 | 0 | Jackson State (249) | Cancelled | - | - |
| 24 | 2021-02-16 | Texas Southern (317) | 0 | 0 | Jackson State (329) | Cancelled | - | - |
| 25 | 2021-02-21 | Prairie View A&M (285) | 77 | 75 | Texas Southern (317) | Final | L | -2 |
| 26 | 2021-02-23 | Mississippi Valley State (365) | 45 | 82 | Texas Southern (317) | Final | W | 37 |
| 27 | 2021-02-25 | Arkansas-Pine Bluff (303) | 65 | 79 | Texas Southern (317) | Final | W | 14 |
| 28 | 2021-02-27 | Texas Southern (317) | 86 | 76 | Alabama State (331) | Final | W | 10 |
| 29 | 2021-03-01 | Texas Southern (198) | 68 | 58 | Alabama A&M (294) | Final | W | 10 |
| 30 | 2021-03-04 | Alcorn State (348) | 78 | 80 | Texas Southern (317) | Final | W | 2 |
| 31 | 2021-03-06 | Southern (259) | 74 | 80 | Texas Southern (317) | Final | W | 6 |
| 32 | 2021-03-11 | Alcorn State (348) | 55 | 78 | Texas Southern (317) | Final | W | 23 |
| 33 | 2021-03-12 | Texas Southern (317) | 84 | 81 | Jackson State (329) | Final/OT | W | 3 |
| 34 | 2021-03-13 | Texas Southern (194) | 80 | 61 | Prairie View A&M (156) | Final | W | 19 |
| 35 | 2021-03-18 | Texas Southern (171) | 60 | 52 | Mount St Mary's (179) | Final | W | 8 |
| 36 | 2021-03-20 | Texas Southern (171) | 66 | 82 | Michigan (4) | Final | L | -16 |