Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-26 | Southern (259) | 78 | 85 | North Carolina Central (341) | Final/OT | L | -7 |
| 2 | 2020-11-27 | Southern (259) | 76 | 103 | Iowa (28) | Final | L | -27 |
| 3 | 2020-12-09 | Southern (259) | 44 | 79 | Arkansas (16) | Final | L | -35 |
| 4 | 2020-12-10 | Southern (259) | 0 | 0 | Gonzaga (11) | Cancelled | - | - |
| 5 | 2020-12-10 | Southern (258) | Gonzaga (4) | Cancelled | - | - | ||
| 6 | 2020-12-16 | Southern (259) | 46 | 88 | UAB (115) | Final | L | -42 |
| 7 | 2020-12-19 | Southern (259) | 0 | 0 | UC-Riverside (292) | Cancelled | - | - |
| 8 | 2020-12-19 | Southern (262) | UC-Riverside (93) | Cancelled | - | - | ||
| 9 | 2020-12-21 | Southern (262) | California Baptist (248) | Cancelled | - | - | ||
| 10 | 2021-01-02 | Prairie View A&M (285) | 0 | 0 | Southern (259) | Cancelled | - | - |
| 11 | 2021-01-03 | Texas Southern (317) | 0 | 0 | Southern (259) | Cancelled | - | - |
| 12 | 2021-01-09 | Southern (259) | 61 | 55 | Grambling (312) | Final | W | 6 |
| 13 | 2021-01-11 | Southern (259) | 0 | 0 | Jackson State (329) | Cancelled | - | - |
| 14 | 2021-01-16 | Arkansas-Pine Bluff (303) | 53 | 88 | Southern (259) | Final | W | 35 |
| 15 | 2021-01-18 | Mississippi Valley State (365) | 61 | 102 | Southern (259) | Final | W | 41 |
| 16 | 2021-01-23 | Southern (259) | 58 | 68 | Alabama A&M (286) | Final | L | -10 |
| 17 | 2021-01-25 | Southern (259) | 64 | 66 | Alabama State (331) | Final | L | -2 |
| 18 | 2021-01-30 | Southern (259) | 76 | 59 | Alcorn State (348) | Final | W | 17 |
| 19 | 2021-02-06 | Grambling (312) | 72 | 69 | Southern (259) | Final | L | -3 |
| 20 | 2021-02-08 | Jackson State (329) | 57 | 53 | Southern (259) | Final | L | -4 |
| 21 | 2021-02-13 | Southern (259) | 73 | 71 | Arkansas-Pine Bluff (303) | Final/OT | W | 2 |
| 22 | 2021-02-17 | Southern (259) | 0 | 0 | Mississippi Valley State (365) | Cancelled | - | - |
| 23 | 2021-02-22 | Alabama State (331) | 66 | 75 | Southern (259) | Final | W | 9 |
| 24 | 2021-02-24 | Alabama A&M (286) | 57 | 73 | Southern (259) | Final | W | 16 |
| 25 | 2021-02-27 | Alcorn State (348) | 75 | 89 | Southern (259) | Final | W | 14 |
| 26 | 2021-03-04 | Southern (259) | 61 | 68 | Prairie View A&M (285) | Final | L | -7 |
| 27 | 2021-03-06 | Southern (259) | 74 | 80 | Texas Southern (317) | Final | L | -6 |
| 28 | 2021-03-11 | Southern (259) | 67 | 72 | Grambling (312) | Final/OT | L | -5 |