Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | South Dakota State (268) | 71 | 79 | West Virginia (50) | Final | L | -8 |
| 2 | 2020-11-26 | Utah State (25) | 59 | 83 | South Dakota State (268) | Final | W | 24 |
| 3 | 2020-11-27 | South Dakota State (268) | 59 | 72 | Saint Mary's (33) | Final | L | -13 |
| 4 | 2020-12-02 | South Dakota State (268) | 71 | 68 | Iowa State (7) | Final | W | 3 |
| 5 | 2020-12-04 | South Dakota State (268) | 88 | 84 | Bradley (113) | Final | W | 4 |
| 6 | 2020-12-10 | North Dakota State (117) | 75 | 77 | South Dakota State (268) | Final | W | 2 |
| 7 | 2020-12-11 | South Dakota State (268) | 74 | 62 | North Dakota (251) | Final | W | 12 |
| 8 | 2020-12-12 | South Dakota (275) | 91 | 78 | South Dakota State (268) | Final | L | -13 |
| 9 | 2021-01-04 | Mount Marty College | 50 | 93 | South Dakota State (113) | Final | W | 43 |
| 10 | 2021-01-08 | Western Illinois (362) | 77 | 83 | South Dakota State (268) | Final | W | 6 |
| 11 | 2021-01-09 | Western Illinois (362) | 63 | 92 | South Dakota State (268) | Final | W | 29 |
| 12 | 2021-01-15 | South Dakota State (268) | 0 | 0 | Nebraska-Omaha (272) | Cancelled | - | - |
| 13 | 2021-01-16 | South Dakota State (268) | 0 | 0 | Nebraska-Omaha (272) | Cancelled | - | - |
| 14 | 2021-01-22 | North Dakota (251) | 73 | 92 | South Dakota State (268) | Final | W | 19 |
| 15 | 2021-01-23 | North Dakota (251) | 74 | 85 | South Dakota State (268) | Final | W | 11 |
| 16 | 2021-01-29 | South Dakota State (268) | 0 | 0 | Denver (253) | Cancelled | - | - |
| 17 | 2021-01-30 | South Dakota State (268) | 0 | 0 | Denver (253) | Cancelled | - | - |
| 18 | 2021-02-05 | South Dakota (275) | 64 | 56 | South Dakota State (268) | Final | L | -8 |
| 19 | 2021-02-06 | South Dakota (275) | 78 | 89 | South Dakota State (268) | Final | W | 11 |
| 20 | 2021-02-13 | South Dakota State (268) | 86 | 103 | Oral Roberts (327) | Final | L | -17 |
| 21 | 2021-02-14 | South Dakota State (268) | 95 | 80 | Oral Roberts (327) | Final | W | 15 |
| 22 | 2021-02-19 | South Dakota State (268) | 68 | 67 | North Dakota State (117) | Final | W | 1 |
| 23 | 2021-02-20 | South Dakota State (268) | 82 | 84 | North Dakota State (117) | Final | L | -2 |
| 24 | 2021-02-26 | UMKC (364) | 49 | 67 | South Dakota State (268) | Final | W | 18 |
| 25 | 2021-02-27 | UMKC (364) | 77 | 89 | South Dakota State (268) | Final | W | 12 |
| 26 | 2021-03-06 | Nebraska-Omaha (272) | 71 | 84 | South Dakota State (268) | Final | W | 13 |
| 27 | 2021-03-08 | Oral Roberts (190) | 90 | 88 | South Dakota State (117) | Final | L | -2 |