NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | South Carolina State (340) | 52 | 80 | Old Dominion (130) | Final | W | 28 |
| 2 | 2021-11-14 | Auburn (163) | 44 | 57 | Old Dominion (130) | Final | W | 13 |
| 3 | 2021-11-18 | George Washington (160) | 47 | 45 | Old Dominion (126) | Final | L | -2 |
| 4 | 2021-11-21 | Old Dominion (62) | 48 | 71 | Virginia Commonwealth (222) | Final | L | -23 |
| 5 | 2021-11-26 | Saint Joseph's (92) | 50 | 67 | Old Dominion (126) | Final | W | 17 |
| 6 | 2021-11-27 | Old Dominion (176) | 59 | 45 | Texas Tech (35) | Final | W | 14 |
| 7 | 2021-11-28 | Stetson (151) | 51 | 61 | Old Dominion (176) | Final | W | 10 |
| 8 | 2021-12-05 | Old Dominion (91) | 68 | 55 | William & Mary (197) | Final | W | 13 |
| 9 | 2021-12-08 | Bowie State | 29 | 70 | Old Dominion (77) | Final | W | 41 |
| 10 | 2021-12-12 | Norfolk State (293) | 47 | 76 | Old Dominion (77) | Final | W | 29 |
| 11 | 2021-12-18 | Old Dominion (126) | 85 | 49 | Appalachian State (226) | Final | W | 36 |
| 12 | 2021-12-22 | Old Dominion (70) | 71 | 68 | Temple (138) | Final | W | 3 |
| 13 | 2021-12-30 | Florida International (198) | 0 | 0 | Old Dominion (70) | Postponed | - | - |
| 14 | 2022-01-01 | Florida Atlantic (284) | 0 | 0 | Old Dominion (70) | Postponed | - | - |
| 15 | 2022-01-08 | Charlotte (167) | 0 | 0 | Old Dominion (126) | Postponed | - | - |
| 16 | 2022-01-13 | Old Dominion (126) | 57 | 46 | UTSA (120) | Final | W | 11 |
| 17 | 2022-01-15 | Old Dominion (72) | 48 | 53 | UTEP (91) | Final | L | -5 |
| 18 | 2022-01-17 | Florida Atlantic (292) | 48 | 61 | Old Dominion (72) | Final | W | 13 |
| 19 | 2022-01-20 | Rice (222) | 59 | 69 | Old Dominion (88) | Final | W | 10 |
| 20 | 2022-01-22 | North Texas (124) | 57 | 67 | Old Dominion (88) | Final | W | 10 |
| 21 | 2022-01-26 | Charlotte (116) | 64 | 61 | Old Dominion (78) | Final | L | -3 |
| 22 | 2022-01-29 | Old Dominion (78) | 54 | 45 | Charlotte (116) | Final | W | 9 |
| 23 | 2022-02-03 | Old Dominion (83) | 62 | 47 | Marshall (172) | Final | W | 15 |
| 24 | 2022-02-05 | Old Dominion (126) | 57 | 71 | Western Kentucky (282) | Final | L | -14 |
| 25 | 2022-02-07 | Florida International (139) | 61 | 73 | Old Dominion (126) | Final | W | 12 |
| 26 | 2022-02-10 | Middle Tennessee (164) | 56 | 58 | Old Dominion (126) | Final | W | 2 |
| 27 | 2022-02-13 | Old Dominion (85) | 81 | 75 | UAB (185) | Final | W | 6 |
| 28 | 2022-02-17 | Marshall (184) | 64 | 48 | Old Dominion (79) | Final | L | -16 |
| 29 | 2022-02-19 | Western Kentucky (115) | 55 | 75 | Old Dominion (79) | Final | W | 20 |
| 30 | 2022-02-24 | Old Dominion (81) | 70 | 55 | Florida Atlantic (303) | Final | W | 15 |
| 31 | 2022-02-26 | Old Dominion (81) | 81 | 69 | Florida International (224) | Final | W | 12 |
| 32 | 2022-03-02 | Louisiana Tech (159) | 65 | 62 | Old Dominion (78) | Final | L | -3 |
| 33 | 2022-03-05 | Old Dominion (78) | 44 | 62 | Middle Tennessee (71) | Final | L | -18 |
| 34 | 2022-03-09 | UTSA (291) | 45 | 65 | Old Dominion (90) | Final | W | 20 |
| 35 | 2022-03-10 | Old Dominion (90) | 58 | 65 | North Texas (123) | Final | L | -7 |
| 36 | 2022-03-18 | Old Dominion (94) | 72 | 66 | Towson (69) | Final | W | 6 |
| 37 | 2022-03-20 | Columbia (74) | 62 | 59 | Old Dominion (94) | Final | L | -3 |