NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Maryland-Eastern Shore | 49 | 84 | Saint Joseph's (210) | Final | L | -35 |
| 2 | 2021-11-13 | Claflin | 57 | 73 | Maryland-Eastern Shore | Final | W | 16 |
| 3 | 2021-11-16 | Bryn Athyn | 28 | 86 | Maryland-Eastern Shore (309) | Final | W | 58 |
| 4 | 2021-11-20 | Drexel (151) | 65 | 60 | Maryland-Eastern Shore (309) | Final | L | -5 |
| 5 | 2021-11-23 | William & Mary (210) | 65 | 58 | Maryland-Eastern Shore (219) | Final | L | -7 |
| 6 | 2021-11-28 | Millersville | 39 | 74 | Maryland-Eastern Shore (305) | Final | W | 35 |
| 7 | 2021-12-01 | Maryland-Eastern Shore (316) | 59 | 69 | Richmond (178) | Final | L | -10 |
| 8 | 2021-12-05 | Navy (280) | 61 | 66 | Maryland-Eastern Shore (316) | Final | W | 5 |
| 9 | 2021-12-08 | Maryland-Eastern Shore (291) | 70 | 77 | La Salle (144) | Final | L | -7 |
| 10 | 2021-12-11 | UNC-Greensboro (275) | 66 | 56 | Maryland-Eastern Shore (291) | Final | L | -10 |
| 11 | 2021-12-18 | Maryland-Eastern Shore (219) | 65 | 82 | Mount St Mary's (270) | Final | L | -17 |
| 12 | 2021-12-21 | Maryland-Eastern Shore (313) | 57 | 85 | East Carolina (175) | Final | L | -28 |
| 13 | 2021-12-29 | Maryland-Eastern Shore (320) | 0 | 0 | West Virginia (63) | Cancelled | - | - |
| 14 | 2022-01-03 | Lancaster Bible | 0 | 0 | Maryland-Eastern Shore (320) | Postponed | - | - |
| 15 | 2022-01-08 | Norfolk State (237) | 0 | 0 | Maryland-Eastern Shore (219) | Postponed | - | - |
| 16 | 2022-01-10 | Maryland-Eastern Shore (219) | 0 | 0 | Howard (116) | Postponed | - | - |
| 17 | 2022-01-15 | Maryland-Eastern Shore (316) | 0 | 0 | Delaware State (349) | Postponed | - | - |
| 18 | 2022-01-17 | Howard (236) | 67 | 52 | Maryland-Eastern Shore (316) | Final | L | -15 |
| 19 | 2022-01-22 | South Carolina State (352) | 54 | 50 | Maryland-Eastern Shore (318) | Final | L | -4 |
| 20 | 2022-01-24 | North Carolina Central (342) | 59 | 81 | Maryland-Eastern Shore (318) | Final | W | 22 |
| 21 | 2022-01-29 | Maryland-Eastern Shore (323) | 57 | 86 | Coppin State (220) | Final | L | -29 |
| 22 | 2022-01-31 | Morgan State (351) | 72 | 60 | Maryland-Eastern Shore (219) | Final | L | -12 |
| 23 | 2022-02-05 | Maryland-Eastern Shore (219) | 66 | 59 | Howard (116) | Final | W | 7 |
| 24 | 2022-02-07 | Norfolk State (237) | 53 | 48 | Maryland-Eastern Shore (219) | Final | L | -5 |
| 25 | 2022-02-09 | Maryland-Eastern Shore (219) | 79 | 46 | Delaware State (348) | Final | W | 33 |
| 26 | 2022-02-12 | Maryland-Eastern Shore (320) | 52 | 66 | Norfolk State (210) | Final | L | -14 |
| 27 | 2022-02-19 | Maryland-Eastern Shore (318) | 65 | 57 | South Carolina State (344) | Final | W | 8 |
| 28 | 2022-02-21 | Maryland-Eastern Shore (318) | 77 | 64 | North Carolina Central (341) | Final | W | 13 |
| 29 | 2022-02-26 | Coppin State (215) | 51 | 60 | Maryland-Eastern Shore (312) | Final | W | 9 |
| 30 | 2022-02-28 | Maryland-Eastern Shore (312) | 60 | 62 | Morgan State (213) | Final | L | -2 |
| 31 | 2022-03-03 | Delaware State (356) | 48 | 66 | Maryland-Eastern Shore (303) | Final | W | 18 |
| 32 | 2022-03-10 | Maryland-Eastern Shore (302) | 73 | 65 | Coppin State (235) | Final | W | 8 |
| 33 | 2022-03-11 | Maryland-Eastern Shore (302) | 54 | 68 | Howard (217) | Final | L | -14 |