NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | William Carey | 42 | 72 | Southern Miss (247) | Final | W | 30 |
| 2 | 2021-11-13 | Louisiana-Monroe (333) | 60 | 77 | Southern Miss (247) | Final | W | 17 |
| 3 | 2021-11-17 | Southern Miss (120) | 54 | 86 | Alabama (117) | Final | L | -32 |
| 4 | 2021-11-20 | Samford (237) | 66 | 71 | Southern Miss (120) | Final | W | 5 |
| 5 | 2021-11-26 | Arkansas-Pine Bluff (306) | 76 | 57 | Southern Miss (197) | Final | L | -19 |
| 6 | 2021-11-27 | Mississippi Valley State (311) | 53 | 72 | Southern Miss (188) | Final | W | 19 |
| 7 | 2021-12-01 | Southern Miss (232) | 64 | 56 | Georgia State (292) | Final | W | 8 |
| 8 | 2021-12-05 | Southern Miss (232) | 71 | 51 | South Alabama (308) | Final | W | 20 |
| 9 | 2021-12-13 | Blue Mountain | 50 | 75 | Southern Miss (176) | Final | W | 25 |
| 10 | 2021-12-19 | Alabama A&M (196) | 55 | 70 | Southern Miss (197) | Final | W | 15 |
| 11 | 2021-12-20 | Richmond (146) | 87 | 75 | Southern Miss (186) | Final | L | -12 |
| 12 | 2021-12-30 | Southern Miss (189) | 88 | 98 | Western Kentucky (169) | Final | L | -10 |
| 13 | 2022-01-01 | Southern Miss (189) | 55 | 72 | Marshall (214) | Final | L | -17 |
| 14 | 2022-01-06 | UTSA (260) | 0 | 0 | Southern Miss (224) | Postponed | - | - |
| 15 | 2022-01-08 | UTEP (257) | 0 | 0 | Southern Miss (197) | Postponed | - | - |
| 16 | 2022-01-09 | Southern Miss (197) | 65 | 59 | Louisiana Tech (68) | Final | W | 6 |
| 17 | 2022-01-13 | Louisiana Tech (68) | 60 | 65 | Southern Miss (197) | Final | W | 5 |
| 18 | 2022-01-17 | UTEP (91) | 49 | 55 | Southern Miss (213) | Final | W | 6 |
| 19 | 2022-01-22 | Middle Tennessee (74) | 81 | 71 | Southern Miss (178) | Final | L | -10 |
| 20 | 2022-01-27 | Southern Miss (197) | 66 | 72 | North Texas (115) | Final | L | -6 |
| 21 | 2022-01-29 | Southern Miss (180) | 78 | 55 | Rice (225) | Final | W | 23 |
| 22 | 2022-02-03 | Florida International (197) | 64 | 65 | Southern Miss (185) | Final | W | 1 |
| 23 | 2022-02-05 | Florida Atlantic (205) | 60 | 79 | Southern Miss (197) | Final | W | 19 |
| 24 | 2022-02-07 | UTSA (120) | 57 | 60 | Southern Miss (197) | Final/OT | W | 3 |
| 25 | 2022-02-10 | UAB (217) | 68 | 61 | Southern Miss (197) | Final | L | -7 |
| 26 | 2022-02-17 | Southern Miss (183) | 66 | 50 | UTSA (289) | Final | W | 16 |
| 27 | 2022-02-19 | Southern Miss (183) | 79 | 86 | UTEP (165) | Final/OT | L | -7 |
| 28 | 2022-02-24 | North Texas (121) | 0 | 0 | Southern Miss (189) | Canceled | - | - |
| 29 | 2022-02-26 | Rice (190) | 51 | 46 | Southern Miss (189) | Final | L | -5 |
| 30 | 2022-03-03 | Southern Miss (196) | 67 | 57 | UAB (199) | Final | W | 10 |
| 31 | 2022-03-05 | Southern Miss (196) | 49 | 70 | Charlotte (85) | Final | L | -21 |
| 32 | 2022-03-09 | Florida International (218) | 60 | 78 | Southern Miss (190) | Final | W | 18 |
| 33 | 2022-03-10 | Southern Miss (190) | 50 | 70 | Middle Tennessee (68) | Final | L | -20 |